Hydrochloric Acid → (6,8-Dichloro-2,4-dihydroxyquinolin-3-yl)(phenyl)methanone

HRID 370469ノート

反応式

HRID 370469 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[N+](C1C=CC=CC=1)([O-])=O.[Cl:23][C:24]1[CH:25]=[C:26]2[C:31](=[C:32]([Cl:34])[CH:33]=1)[NH:30][C:29](=[O:35])[CH:28]=[C:27]2[OH:36].Cl>O>[C:1]([C:28]1[C:29](=[O:35])[NH:30][C:31]2[C:26]([C:27]=1[OH:36])=[CH:25][C:24]([Cl:23])=[CH:33][C:32]=2[Cl:34])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 7412Benzoyl chlorideHCID 7416NitrobenzeneHCID 6451240Aluminum(III) ChlorideHCID 546956806,8-Dichloro-4-hydroxy-2-quinolone

生成物 1

HCID 135687075(6,8-Dichloro-2,4-dihydroxyquinolin-3-yl)(phenyl)methanone収率 65.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Benzoyl chloride (0.93 gram) is added to a mixture of 1.5 grams of anhydrous aluminum chloride and 10 ml of nitrobenzene, the mixture is stirred at room temperature until it becomes uniform, stirred at 105° to 110° C. for eight hours with 1.26 grams of 6,8-dichloro-4-hydroxy-2-quinolone, decomposed with concentrated hydrochloric acid, small amount of water is added thereto, and crystals separated out therefrom are collected by filtration. The crystals are washed with water and then washed with methanol and ether to give 1.2 grams of 3-benzoyl-6,8-dichloro-4-hydroxy-2-quinolone, pale yellow powder, melting point 258° to 259° C.

後処理

  1. additionis added
  2. customcrystals separated
  3. filtrationout therefrom are collected by filtration
  4. washThe crystals are washed with water
  5. washwashed with methanol and ether

出典と根拠

ORDレコード
ord-e958c3d4a36345979d15fb506dabea24
出典データセット
uspto-grants-1985_07
特許番号
US04526894

反応ノート

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