Potassium Carbonate → Methyl (4-allylthio-3-ethylazetidin-2-on-1-yl)acetate

HRID 370508ノート

反応式

HRID 370508 の反応式
[CH2:1]([S:4][CH:5]1[NH:8][C:7](=[O:9])[CH:6]1[CH2:10][CH3:11])[CH:2]=[CH2:3].Br[CH2:13][C:14]([O:16][CH3:17])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:17][O:16][C:14](=[O:15])[CH2:13][N:8]1[CH:5]([S:4][CH2:1][CH:2]=[CH2:3])[CH:6]([CH2:10][CH3:11])[C:7]1=[O:9]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 131064924-Allylthio-3-ethylazetidinone

生成物 1

HCID 13106494Methyl (4-allylthio-3-ethylazetidin-2-on-1-yl)acetate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 2.34 g of 4-allylthio-3-ethylazetidinone in 20 ml of redistilled dimethylformamide were added 1.37 ml of methyl bromoacetate and 4.16 g of ground potassium carbonate. The solution was stirred overnight then filtered through a pad of Hyflo, (Hyflo being a Trade Mark), poured into 75 ml of water, and extracted five times with ethyl acetate. The combined organic extracts were washed with water, dried over magnesium sulphate, and evaporated in vacuo to give the title compound. (Yield 3 g)

後処理

  1. filtrationthen filtered through a pad of Hyflo
  2. additionpoured into 75 ml of water
  3. extractionextracted five times with ethyl acetate
  4. washThe combined organic extracts were washed with water
  5. dry with materialdried over magnesium sulphate
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-2d84188b4a56427bb449539e0dfcdc04
出典データセット
uspto-grants-1985_07
特許番号
US04526718

反応ノート

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