2-Ethylamino-4,6-dichloro-5-methylthio-pyrimidine → Ammonia

HRID 370618ノート

反応式

HRID 370618 の反応式
[CH2:1]([NH:3][C:4]1[N:9]=[C:8]([Cl:10])[C:7]([S:11][CH3:12])=[C:6]([Cl:13])[N:5]=1)[CH3:2].C([NH:16]C1C(SC)=C(Cl)N=C(Cl)N=1)C>CO>[CH2:1]([NH:3][C:4]1[N:5]=[C:6]([Cl:13])[C:7]([S:11][CH3:12])=[C:8]([Cl:10])[N:9]=1)[CH3:2].[NH3:16]

参加物

5

反応物 2

HCID 155677722-Ethylamino-4,6-dichloro-5-methylthio-pyrimidineHCID 20274851HCID 20274851、化合物

生成物 2

HCID 222AmmoniaHCID 155677722-Ethylamino-4,6-dichloro-5-methylthio-pyrimidine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2.5 Grams of 2-ethylamino-4,6-dichloro-5-methylthio-pyrimidine, 9 g of the mixture of 2-ethylamino-4,6-dichloro-5-methylthio-pyrimidine and 4-ethylamino-2,6-dichloro-5-methylthio-pyrimidine obtained in the first stage of Example 1, 165 g of methanol and 16 g of ammonia are introduced into a 500 ml autoclave. The mixture is heated for 2 hours at 120° C., then cooled. The solution obtained is concentrated under reduced pressure and the residue is washed with water. 8.2 Grams of a mixture melting at 76° C. are thus obtained. The analysis of the mixture by gas chromatography and mass spectrometry shows that it contains 56.6% of 2-amino-6-chloro-4-ethylamino-5-methylthio-pyrimidine, 37.8% of 4-amino-2-ethylamino-6-chloro-5-methylthio-pyrimidine and 5.6% of 6-amino-4-ethylamino-2-chloro-5-methylthio-pyrimidine.

出典と根拠

ORDレコード
ord-5cebb6bc5b624cfc8bf80f188d62635b
出典データセット
uspto-grants-1985_07
特許番号
US04528026

反応ノート

読み込み中…