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Trifluoroacetic acid → 4-[2-[2-(3-Carboxypropylcarbamoyl)phenyldisulfanyl]benzoylamino] butanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Anisole | HCID 7519 | — |
| 反応物 | 4,4'-[Dithiobis(2,1-phenylenecarbonylimino)]bis butanoic acid bis (1,1-dimethylethyl)ester | HCID 86751258 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-[2-[2-(3-Carboxypropylcarbamoyl)phenyldisulfanyl]benzoylamino] butanoic acid | HCID 468886 | 139.9% |
反応手順
This compound was prepared according to the procedure described in Example 50 using 4,4'-[dithiobis(2,1-phenylenecarbonylimino)]bis butanoic acid bis (1,1-dimethylethyl) ester (0.5 g, 0.9 mmol) from Example 43, 10 mL dichloromethane, 10 mL trifluoroacetic acid, and 1 mL anisole. The crude product was recrystallized from methanol/dimethylformamide/water to afford 0.6 g of the title compound, mp 165°-166° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05734081 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-f5ac2919a37f4d268e8ee62516c10df4 |
| 出典メモ | uspto-grants-1998_03 |