Acetic Acid → 6-(2-Hydroxyphenyl)-3(2H)-pyridazinone

HRID 370752ノート

反応式

HRID 370752 の反応式
O[CH:2]([CH2:6][C:7](=O)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14])[C:3](O)=[O:4].[NH3:16].[NH2:17]N.C(O)(=O)C>O>[OH:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:7]1[CH:6]=[CH:2][C:3](=[O:4])[NH:16][N:17]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 222Ammonia2 回HCID 9321HydrazineHCID 13778436HCID 13778436、化合物

生成物 1

HCID 30173466-(2-Hydroxyphenyl)-3(2H)-pyridazinone収率 85%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirred suspension of 2-hydroxy-4-oxo-4-(2-hydroxyphenyl)butyric acid in water was added ammonia until pH 7.0 was attained. Hydrazine was added slowly with the concurrent addition of sufficient glacial acetic acid to maintain a pH of 7.0. Steam heating was applied for 2 hours and during this time the pH of 7.0 was maintained by the addition of ammonia as necessary. The reaction mixture was allowed to cool to room temperature. The solid was filtered off, washed with water, 2-propanol and dried (MgSO4) to afford 6-(2-hydroxyphenyl)-3(2H)-pyridazinone (85%).

後処理

  1. temperatureto maintain a pH of 7.0
  2. temperatureSteam heating
  3. filtrationThe solid was filtered off
  4. washwashed with water, 2-propanol
  5. dry with materialdried (MgSO4)

出典と根拠

ORDレコード
ord-caf4335781aa4d75bb4cdf7359c0a5b8
出典データセット
uspto-grants-1985_07
特許番号
US04528371

反応ノート

読み込み中…