Potassium Hydroxide → Dimethyl (2-methoxy-phenylsulphanyl)malonate

HRID 37101

反応式

HRID 37101 の反応式
[OH-].[K+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[SH:11].Cl[CH:13]([C:18]([O:20][CH3:21])=[O:19])[C:14]([O:16][CH3:17])=[O:15]>C(O)C>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11][CH:13]([C:18]([O:20][CH3:21])=[O:19])[C:14]([O:16][CH3:17])=[O:15]

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 23642ThioguaiacolHCID 120070Dimethyl chloromalonate

生成物 1

HCID 22362038Dimethyl (2-methoxy-phenylsulphanyl)malonate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

1 g of KOH was added to a solution of 2.2 ml of 2-methoxythiophenol in 30 ml of ethanol. The reaction mixture was treated at room temperature with a solution of dimethyl chloromalonate in 5 ml of ethanol, stirred for 1 hour and evaporated. The residue was partitioned between ether and water. The organic phase was dried, concentrated and the residue was purified over silica gel with methylene chloride. 3.6 g of dimethyl (2-methoxy-phenylsulphanyl)malonate, MS: M=270, were obtained.

後処理

  1. customevaporated
  2. customThe residue was partitioned between ether and water
  3. customThe organic phase was dried
  4. concentrationconcentrated
  5. customthe residue was purified over silica gel with methylene chloride

出典と根拠

ORDレコード
ord-19e57d3a32fb454487ce6ca1e155c744
出典データセット
uspto-grants-1995_05
特許番号
US05420129

関連ノート

読み込み中…