Hydrochloric Acid → 4-(3,5-Dichloro-pyridin-2-yloxy)-phenol

HRID 371035ノート

反応式

HRID 371035 の反応式
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.[C:10]1([CH:17]=[CH:16][C:14]([OH:15])=[CH:13][CH:12]=1)[OH:11].[OH-].[K+].Cl>O.CS(C)=O>[Cl:8][C:7]1[C:2]([O:11][C:10]2[CH:17]=[CH:16][C:14]([OH:15])=[CH:13][CH:12]=2)=[N:3][CH:4]=[C:5]([Cl:9])[CH:6]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 785HydroquinoneHCID 14797Potassium HydroxideHCID 27666Pyridine, 2,3,5-trichloro-

生成物 1

HCID 6208804-(3,5-Dichloro-pyridin-2-yloxy)-phenol

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

A mixture of 2,3,5-trichloropyridine (2.5 g, 13.7 mm), hydroquinone (3.02 g, 27.4 mm), KOH (3.07 g, 54.8 mm) and DMSO (10 ml) is heated to 160° for 3 hours. The mixture is poured into water, acidified with dilute HCl and extracted with ether. The ethereal solution is washed, dried and evaporated to dryness. The crude product is chromatographed on silica gel to give crystalline 4-(3,5-dichloropyridyloxy)phenol.

後処理

  1. temperatureis heated to 160° for 3 hours
  2. extractionextracted with ether
  3. washThe ethereal solution is washed
  4. customdried
  5. customevaporated to dryness
  6. customThe crude product is chromatographed on silica gel

出典と根拠

ORDレコード
ord-4f564ecb133e48fe8515d942dea3c6d6
出典データセット
uspto-grants-1985_07
特許番号
US04529438

反応ノート

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