Ethanol → HCID 20262414、化合物

HRID 371104ノート

反応式

HRID 371104 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[C:23](=[O:24])[N:22]4[C:25]([CH3:28])=[CH:26][S:27][C:21]4=[N:20][C:19]=3[CH3:29])[CH2:12][CH2:11]2)=[CH:2]1.C(O)C.[P:33](=[O:37])([OH:36])([OH:35])[OH:34]>O>[P:33]([OH:37])([OH:36])([OH:35])=[O:34].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[C:23](=[O:24])[N:22]4[C:25]([CH3:28])=[CH:26][S:27][C:21]4=[N:20][C:19]=3[CH3:29])[CH2:12][CH2:11]2)=[CH:2]1

参加物

5

反応物 3

HCID 702EthanolHCID 1004Phosphoric AcidHCID 30861076-(2-(4-(1H-Indol-3-yl)piperidin-1-yl)ethyl)-3,7-dimethyl-5H-thiazolo(3,2-a)pyrimidin-5-one

生成物 1

HCID 20262414HCID 20262414、化合物収率 80%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A stirred and warm suspension of 4 parts of 6-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one in 80 parts of ethanol was acidified with phosphoric acid. 60 parts of water were added and the whole was boiled. The undissolved material was filtered off and the filtrate was allowed to crystallize. The product was filtered off and dried, yielding 4.5 parts (80%) of 6-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one phosphate (2:3) monohydrate; mp. 214.4° C. (compound 28).

後処理

  1. temperaturewarm
  2. filtrationThe undissolved material was filtered off
  3. customto crystallize
  4. filtrationThe product was filtered off
  5. customdried

出典と根拠

ORDレコード
ord-d9a01389ac6a4d459c90fdd5f5812f19
出典データセット
uspto-grants-1985_07
特許番号
US04529727

反応ノート

読み込み中…