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Ketoprofen → Phthalidyl 2-(3-benzoylphenyl)propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ketoprofen | HCID 3825 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1(3H)-Isobenzofuranone, 3-bromo- | HCID 96218 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Phthalidyl 2-(3-benzoylphenyl)propionate | HCID 12769703 | 79% |
反応手順
To a solution of 7.6 g of 2-(3-benzoylphenyl)propionic acid in 30 ml of chloroform and 3.4 g of triethylamine is added a solution of 6.2 g of 3-bromophthalide in 20 ml of chloroform. The solution thus obtained is stirred 25 hours at room temperature, the organic phase is washed with an aqueous solution of sodium bicarbonate, then with water and finally dried on anhydrous sodium sulfate and evaporated to dryness to give the phthalidyl 2-(3-benzoylphenyl)propionate; yield 79%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04529737 |
| 出典データセット | uspto-grants-1985_07 |
| ORD ID | ord-13e304f3ba35400987a80225de0e105e |
| 出典メモ | uspto-grants-1985_07 |