ethyl (3,4-dihydro-6-nitro-3-oxo-2H-1,4-benzoxazin-4-yl)acetate → 2-(3,4-dihydro-6-nitro-3-oxo-2H-1,4-benzoxazin-4-yl)-N-methylacetamide

HRID 37124

反応式

HRID 37124 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH2:11][C:10](=[O:13])[N:9]([CH2:14][C:15]([O:17]CC)=O)[C:8]=2[CH:20]=1)([O-:3])=[O:2].[CH3:21][NH2:22].CO>C(Cl)Cl>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH2:11][C:10](=[O:13])[N:9]([CH2:14][C:15]([NH:22][CH3:21])=[O:17])[C:8]=2[CH:20]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 10492982ethyl (3,4-dihydro-6-nitro-3-oxo-2H-1,4-benzoxazin-4-yl)acetateHCID 57454252Monomethylamine methanol

生成物 1

HCID 113461112-(3,4-dihydro-6-nitro-3-oxo-2H-1,4-benzoxazin-4-yl)-N-methylacetamide収率 42.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In 1.5 ml of methylene chloride were dissolved 0.5 g of ethyl (3,4-dihydro-6-nitro-3-oxo-2H-1,4-benzoxazin-4-yl)acetate and 0.16 g of 40% methylamine-methanol and the mixture was allowed to stand at room temperature for 3 days. The solvent was then distilled off and the residue was recrystallized from methylene chloride-hexane to give 0.2 g of 2-(3,4-dihydro-6-nitro-3-oxo-2H-1,4-benzoxazin-4-yl)-N-methylacetamide. This compound has the following physicochemical properties.

後処理

  1. distillationThe solvent was then distilled off
  2. customthe residue was recrystallized from methylene chloride-hexane

出典と根拠

ORDレコード
ord-b9fb4f5a5934449495f49c5c4dbe0455
出典データセット
uspto-grants-1995_05
特許番号
US05420126

関連ノート

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