Methanol → Methyl 3-Hydroxyphenylacetate
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[CH3:17]O>>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:17])=[O:10])[CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
To a solution of 3-hydroxyphenylacetic acid (2 g, 13.2 mmol) in methanol (45 mL) was added concentrated H2SO4 (0.82 mL) and the mixture was heated at reflux for 18 h. Next, the solvent was removed and the residue was diluted with water and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and the solvent was removed, to yield 1.54 g of the desired compound (yield: 71%).
後処理
- temperaturethe mixture was heated
- temperatureat reflux for 18 h
- customNext, the solvent was removed
- additionthe residue was diluted with water
- extractionextracted with ethyl acetate
- dry with materialThe organic phase was dried over anhydrous sodium sulfate
- customthe solvent was removed
出典と根拠
- ORDレコード
- ord-bf58182e499b4b8590ee23072ae2a58a
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05420131
反応ノート
読み込み中…