Methanol → Methyl 3-Hydroxyphenylacetate

HRID 37129

反応式

HRID 37129 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[CH3:17]O>>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:17])=[O:10])[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 121223'-Hydroxyphenylacetic acid

生成物 1

HCID 39129Methyl 3-Hydroxyphenylacetate収率 71%

実験手順

To a solution of 3-hydroxyphenylacetic acid (2 g, 13.2 mmol) in methanol (45 mL) was added concentrated H2SO4 (0.82 mL) and the mixture was heated at reflux for 18 h. Next, the solvent was removed and the residue was diluted with water and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and the solvent was removed, to yield 1.54 g of the desired compound (yield: 71%).

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 18 h
  3. customNext, the solvent was removed
  4. additionthe residue was diluted with water
  5. extractionextracted with ethyl acetate
  6. dry with materialThe organic phase was dried over anhydrous sodium sulfate
  7. customthe solvent was removed

出典と根拠

ORDレコード
ord-bf58182e499b4b8590ee23072ae2a58a
出典データセット
uspto-grants-1995_05
特許番号
US05420131

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