Chloromethyl(4-phenylphenyl)divinylsilane → Divinyl(1H-imidazol-1-ylmethyl)(4-phenylphenyl)silane

HRID 371315ノート

反応式

HRID 371315 の反応式
Cl[CH2:2][Si:3]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)([CH:6]=[CH2:7])[CH:4]=[CH2:5].[NH:20]1[CH:24]=[CH:23][N:22]=[CH:21]1.[K]>C1(C)C=CC=CC=1.[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH:4]([Si:3]([CH:6]=[CH2:7])([CH2:2][N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1)[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)=[CH2:5]

参加物

5

反応物 2

HCID 20273719Chloromethyl(4-phenylphenyl)divinylsilaneHCID 67086713Potassium imidazole

生成物 1

HCID 13489959Divinyl(1H-imidazol-1-ylmethyl)(4-phenylphenyl)silane

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒HCID 1140Toluene溶媒

実験手順

To a solution of 1.14 g (0.004 mol) of chloromethyl(4-phenylphenyl)divinylsilane in 10 ml of toluene is added 0.54 g (0.005 mol) of potassium imidazole and 0.05 g of tetrabutylammonium bromide. The mixture is refluxed under nitrogen for two days, cooled, diluted with ether-hexanes, and washed with water and brine. Removal of solvent gives an oil which is purified by silica gel chromatography, eluting with 9:1 dichloromethane-ether, to give the title compound.

後処理

  1. temperatureThe mixture is refluxed under nitrogen for two days
  2. temperaturecooled
  3. washwashed with water and brine
  4. customRemoval of solvent
  5. customgives an oil which
  6. customis purified by silica gel chromatography
  7. washeluting with 9:1 dichloromethane-ether

出典と根拠

ORDレコード
ord-9f4c7b118be645d997e352a54cb7baa0
出典データセット
uspto-grants-1985_07
特許番号
US04530922

反応ノート

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