Hydrochloric Acid → 1,1,1-Trifluorooct-3-yn-2-ol
反応式
[CH2:1]=[CH:2][CH2:3][CH2:4][CH2:5][CH3:6].C([Li])CCC.[F:12][C:13]([F:17])([F:16])[CH:14]=[O:15].Cl>C(OCC)C>[F:12][C:13]([F:17])([F:16])[CH:14]([OH:15])[C:1]#[C:2][CH2:3][CH2:4][CH2:5][CH3:6]参加物
6
実験手順
1-hexene (6.2 g, 76 mmol) and n-butyllithium (52 ml, 1.5 M in hexane) and trifluoroacetaldehyde (7 g, 71 mmol) were reacted 3 hours under the action of ultrasonic irradiation (as generated by a commercially available ultrasonic cleaner 220H manufactured by Branson Cleaning Equipment Company). The reaction mixture was poured into aqueous 2% HCl solution and diethyl ether was used for extraction of the oily layer. The extracts were then distilled to give 1,1,1-trifluoro-3-octyne-2-ol (b.p.: 83-85° C./21 mmHg) in a yield of 72%. This hydroxyalkyne gave the following analytical data:
後処理
- extractionwas used for extraction of the oily layer
- distillationThe extracts were then distilled
出典と根拠
- ORDレコード
- ord-9a27667bca2b49d0b04d637ccbe6f1ac
- 出典データセット
- uspto-grants-1985_07
- 特許番号
- US04532020
反応ノート
読み込み中…