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Ethyl orthoformate → 7-Chloro-5-methylthio-1,2,4-triazolo[4,3-c]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | 4-Chloro-6-hydrazinyl-2-(methylsulfanyl)pyrimidine | HCID 1484546 | — |
| 生成物 | 7-Chloro-5-methylthio-1,2,4-triazolo[4,3-c]pyrimidine | HCID 13519858 | — |
反応手順
A mixture of 7.0 g (0.037 mole) of 4-chloro-6-hydrazino-2-methylthiopyrimidine and 100 ml of triethyl orthoformate was heated at reflux for 48 hours. Cooling provided a precipitate which was isolated by filtration, and then recrystallized from an ethanol-heptane mixture, with treatment with decolorizing charcoal. The product was red crystals of 7-chloro-5-methylthio-1,2,4-triazolo[4,3-c]pyrimidine, m.p. 164°-165° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04532242 |
| 出典データセット | uspto-grants-1985_07 |
| ORD ID | ord-2132604681b044c0af377e7cdc2929c9 |
| 出典メモ | uspto-grants-1985_07 |