6-Methyluracil → 2,4(1H,3H)-Pyrimidinedione, 5-bromo-6-methyl-

HRID 371455

反応式

HRID 371455 の反応式
[Br:1]Br.[CH3:3][C:4]1[NH:9][C:8](=[O:10])[NH:7][C:6](=[O:11])[CH:5]=1>C(O)(=O)C>[Br:1][C:5]1[C:6](=[O:11])[NH:7][C:8](=[O:10])[NH:9][C:4]=1[CH3:3]

参加物

4

反応物 2

HCID 122836-MethyluracilHCID 24408Bromine

生成物 1

HCID 847572,4(1H,3H)-Pyrimidinedione, 5-bromo-6-methyl-収率 77.9%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Bromine (39.97 g, 0.25 mole) was added dropwise to a cooled mixture of 31.5 g (0.25 mole) of 6-methyl-2,4(1H,3H)pyrimidinedione in 200 ml of glacial acetic acid. The resulting mixture was stirred at ambient temperature for 16 hours and then filtered. The solid which was collected was washed with water and dried in vacuo overnight at 69° C. to give 39.9 g of the product as a white solid, mp 254° C. (dec.).

後処理

  1. filtrationfiltered
  2. customThe solid which was collected
  3. washwas washed with water
  4. customdried in vacuo overnight at 69° C.

出典と根拠

ORDレコード
ord-75d36cdee415432186b42c2d574b37a0
出典データセット
uspto-grants-1985_07
特許番号
US04532240

関連ノート

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