Hydrochloric Acid → 1-(2-Hydroxy-4,6-dimethylphenyl)-1-butanone

反応式

C([O:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[C:9]([CH3:14])[CH:8]=1)(=O)CCC.[Cl-].[Al+3].[Cl-].[Cl-].Cl>>[C:7]([C:12]1[C:11]([CH3:13])=[CH:10][C:9]([CH3:14])=[CH:8][C:7]=1[OH:6])(=[O:6])[CH2:8][CH2:9][CH3:10]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 532286Butyric acid, 3,5-dimethylphenyl ester

HCID 6451240Aluminum(III) Chloride

生成物 1

HCID 42010061-(2-Hydroxy-4,6-dimethylphenyl)-1-butanone

反応条件

温度: 70 °C

実験手順

180 g. of 1-butyryloxy-3,5-dimethyl-benzene are treated at room temperature with 340 g. of aluminium chloride. The mixture is stirred for 4 hours at 90°-95° C., then cooled at 70° C., poured onto ice and 3n aqueous hydrochloric acid and extracted with ether. The ether extract is washed with water to neutral reaction, dried over sodium sulfate and evaporated. There is obtained 2-butyryl-3,5-dimethyl-phenol, which melts at 48°-52° C. after recrystallization from petroleum ether.