Ethanol → 3-(Ethoxycarbonyl)benzoic acid

HRID 371609ノート

反応式

HRID 371609 の反応式
[C:1]([O:14]CC)(=[O:13])[C:2]1[CH:12]=[CH:11][CH:10]=[C:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH:3]=1.C(O)C.[OH-].[K+]>O>[C:5]([O:7][CH2:8][CH3:9])(=[O:6])[C:4]1[CH:10]=[CH:11][CH:12]=[C:2]([C:1]([OH:14])=[O:13])[CH:3]=1

参加物

5

反応物 3

HCID 702EthanolHCID 12491Diethyl isophthalateHCID 14797Potassium Hydroxide

生成物 1

HCID 8167713-(Ethoxycarbonyl)benzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 55 g. of this diethyl isophthalate in 140 ml. of ethanol was saponified by the addition of 15 g. of potassium hydroxide in 15 ml. of water. The resulting gel was refluxed 30 minutes, cooled and extracted with ether to remove unreacted diester. The water layer was acidified and the crude acid product precipitated. Ethyl hydrogen isophthalate having a melting point of 131° to 132° C. was obtained in a 16.5 g. yield after recrystallization from benzene.

後処理

  1. temperatureThe resulting gel was refluxed 30 minutes
  2. temperaturecooled
  3. extractionextracted with ether
  4. customto remove unreacted diester
  5. customthe crude acid product precipitated

出典と根拠

ORDレコード
ord-d5a50fb553ec478ab321549326c6685c
出典データセット
uspto-grants-1978_05
特許番号
US04087409

反応ノート

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