Tert-Butylamine → [(t-Butylcarbamoyl)methyl]phosphonic acid

HRID 371700

反応式

HRID 371700 の反応式
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].[C:6]([CH2:9][P:10](=[O:15])([O:13]C)[O:11]C)(O)=[O:7].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[C:1]([NH:5][C:6]([CH2:9][P:10](=[O:11])([OH:15])[OH:13])=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 6385Tert-ButylamineHCID 10868DicyclohexylcarbodiimideHCID 1899642-(Dimethoxyphosphoryl)acetic acid

生成物 1

HCID 22748653[(t-Butylcarbamoyl)methyl]phosphonic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Tertiary butyl amine (0.045 mole) and dimethyl (carboxymethyl)phosphonate (0.04 mole) were dissolved in 100 ml. of methylene chloride. As the solution was stirred, dicyclohexylcarbodiimide was added portionwise. The solution was stirred overnight and the mixture filtered. The filtrate was concentrated to a solid. It was recrystallized from an appropriate solvent such as methanol. m.p. 163°-5° C., yield, 61%.

後処理

  1. stirringThe solution was stirred overnight
  2. filtrationthe mixture filtered
  3. concentrationThe filtrate was concentrated to a solid
  4. customIt was recrystallized from an appropriate solvent such as methanol
  5. customm.p. 163°-5° C., yield

出典と根拠

ORDレコード
ord-fdc5e424f1ab4d7eb193b14a80ef3588
出典データセット
uspto-grants-1978_05
特許番号
US04087522

関連ノート

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