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Water → 19-Methoxyandrost-4-ene-3,17-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 19-Hydroxyandrostenedione | HCID 252379 | — |
| 反応物 | Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) | HCID 2735153 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 19-Methoxyandrost-4-ene-3,17-dione | HCID 54153042 | — |
反応手順
19-Hydroxyandrost-4-ene-3,17-dione is dissolved in methylenechloride and trimethyloxonium fluoroborate added. After stirring at room temperature for a period of two hours, water is added to the reaction mixture, the organic layer is separated, dried over magnesium sulfate and the solvent removed under vacuum. The residue is crystallized from an acetone-hexane solution to yield the desired 19-methoxyandrost-4-ene-3,17-dione.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04087524 |
| 出典データセット | uspto-grants-1978_05 |
| ORD ID | ord-375ad16dbc2f48c98abcf840ec02c66b |
| 出典メモ | uspto-grants-1978_05 |