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Pyridine → 19-t-Butyldimethylsiloxy-4-androstene-3,17-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 反応物 | 19-Hydroxyandrostenedione | HCID 252379 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 19-t-Butyldimethylsiloxy-4-androstene-3,17-dione | HCID 10573974 | — |
反応手順
19-Hydroxy-4-androstene-3,17-dione, t-butyldimethylsilylchloride and pyridine are mixed in dry dimethylformamide and heated on a steam bath overnight. The reaction mixture is poured onto water and stirred well for 15 minutes. The resulting solid is filtered and dissolved in methylenechloride, dried over magnesium sulfate and the solvent removed. The residue is crystallized from an acetone-hexane solution to yield 19-t-butyldimethylsiloxy-4-androstene-3,17-dione.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04087524 |
| 出典データセット | uspto-grants-1978_05 |
| ORD ID | ord-0d06e6505c2c4bc38a1a215cd98f8202 |
| 出典メモ | uspto-grants-1978_05 |