Sodium Bicarbonate → 1alpha-Methyl-4-androstene-17beta,19-diol 17-propionate

HRID 371832ノート

反応式

HRID 371832 の反応式
[C:1]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]2[C@H:12]3[C@H:27]([CH2:28][CH2:29][C@:7]12[CH3:8])[C@:20]1([CH2:21][O:22]C(=O)CC)[C:15](=[CH:16][CH2:17][CH2:18][C@@H:19]1[CH3:30])[CH2:14][CH2:13]3)(=[O:4])[CH2:2][CH3:3].C(=O)(O)[O-].[Na+]>CO>[C:1]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]2[C@H:12]3[C@H:27]([CH2:28][CH2:29][C@:7]12[CH3:8])[C@:20]1([CH2:21][OH:22])[C:15](=[CH:16][CH2:17][CH2:18][C@@H:19]1[CH3:30])[CH2:14][CH2:13]3)(=[O:4])[CH2:2][CH3:3]

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 705838891alpha-Methyl-4-androstene-17beta,19-diol dipropionate

生成物 1

HCID 705847651alpha-Methyl-4-androstene-17beta,19-diol 17-propionate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 1α-methyl-4-androstene-17β,19-diol dipropionate in 10% aqueous methanol is added 1 equivalent sodium bicarbonate and the solution is heated under reflux for one hour. Methanol is removed under vacuum to half volume and the concentrate is poured onto water. The solid is filtered, air dried and crystallized from hexane to give 1α-methyl-4-androstene-17β,19-diol 17-propionate.

後処理

  1. temperaturethe solution is heated
  2. temperatureunder reflux for one hour
  3. customMethanol is removed under vacuum to half volume
  4. additionthe concentrate is poured onto water
  5. filtrationThe solid is filtered
  6. customair dried
  7. customcrystallized from hexane

出典と根拠

ORDレコード
ord-787362debebf4459818e6891b21939ee
出典データセット
uspto-grants-1978_05
特許番号
US04087524

反応ノート

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