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Potassium Carbonate → 2-[3-[4-[[5-Methyl-2-(1-methylethyl)phenoxy]methyl]piperid-1-yl]propyl]-1H-isoindole-1,3(2H)-dione

HRID 37189
ノート
印刷プレビュー

反応式

HRID 37189 の反応式
Cl.[CH3:2][C:3]1[CH:4]=[CH:5][C:6]([CH:17]([CH3:19])[CH3:18])=[C:7]([CH:16]=1)[O:8][CH2:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.Br[CH2:21][CH2:22][CH2:23][N:24]1[C:32](=[O:33])[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]1=[O:34].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:2][C:3]1[CH:4]=[CH:5][C:6]([CH:17]([CH3:19])[CH3:18])=[C:7]([CH:16]=1)[O:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:21][CH2:22][CH2:23][N:24]2[C:32](=[O:33])[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:25]2=[O:34])[CH2:12][CH2:11]1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 21611N-3-BromopropylphthalimideHCID 19934805HCID 19934805、化合物

生成物 1

HCID 199348062-[3-[4-[[5-Methyl-2-(1-methylethyl)phenoxy]methyl]piperid-1-yl]propyl]-1H-isoindole-1,3(2H)-dione

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

11.35 g (0.04 mol) of 4-[[5-methyl-2-(1methylethyl)phenoxy]methyl]piperidine hydrochloride, 10.72 g (0.04 mol) of 2-(3-bromopropyl)-1H-isoindole-1,3(2H)-dione and 13.8 g (0.1 mol) of potassium carbonate are reacted in 113 ml of N,N-dimethylformamide. The mixture is stirred for 3 h at 100° C. It is poured into ice-cold water. The solution is extracted with ethyl acetate and it is washed with water. The organic phase is dried over sodium sulphate, filtered and concentrated under reduced pressure. The product obtained is used as is in the following stage.

後処理

  1. additionIt is poured into ice-cold water
  2. extractionThe solution is extracted with ethyl acetate and it
  3. washis washed with water
  4. dry with materialThe organic phase is dried over sodium sulphate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customThe product obtained

出典と根拠

ORDレコード
ord-64f3955d8a51403ab6446bc3f2373b4e
出典データセット
uspto-grants-1995_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05420130

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート