7-chloro-3-ethyl-5-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid, ethyl ester → 3,5-dimethyl-7-ethoxy-3H-imidazo-[4,5-b]pyridine-6-carboxylic acid, ethyl ester
反応式
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([CH3:13])[N:5]=[C:4]2[N:14]([CH2:17]C)[CH:15]=[N:16][C:3]=12.[CH2:19]([O:21]C(C1C(Cl)=C2N=CN(C)C2=NC=1C)=O)[CH3:20]>>[CH3:17][N:14]1[C:4]2=[N:5][C:6]([CH3:13])=[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:2]([O:21][CH2:19][CH3:20])=[C:3]2[N:16]=[CH:15]1参加物
3
実験手順
By replacing 7-chloro-3-ethyl-5-methyl-3H-imidazo-[4,5-b]pyridine-6-carboxylic acid, ethyl ester in Example 1 e with 7-chloro-3,5-dimethyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid ethyl ester, 3,5-dimethyl-7-ethoxy-3H-imidazo[4,5-b]pyridine -6-carboxylic acid, ethyl ester is obtained. Yield 78%, m.p. 85°-87° (ether).