5-Amino-6-ethylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester → 3-butyl-7-chloro-5-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid, ethyl ester
反応式
N[C:2]1C(Cl)=C(C(OCC)=O)C(C)=NC=1NCC.[NH2:18][C:19]1[C:20]([Cl:36])=[C:21]([C:31]([O:33][CH2:34][CH3:35])=[O:32])[C:22]([CH3:30])=[N:23][C:24]=1[NH:25][CH2:26][CH2:27][CH2:28][CH3:29]>>[CH2:26]([N:25]1[C:24]2=[N:23][C:22]([CH3:30])=[C:21]([C:31]([O:33][CH2:34][CH3:35])=[O:32])[C:20]([Cl:36])=[C:19]2[N:18]=[CH:2]1)[CH2:27][CH2:28][CH3:29]参加物
3
実験手順
By replacing 5-amino-6-ethylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester in Example 1 d with 5-amino-6-butylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester, 3-butyl-7-chloro-5-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid, ethyl ester is obtained. Yield 83%, b.p. 190°-200°/0.01.