Benzene → 3-Cyclopropylcarbonyl-1-phenyl-3-azabicyclo[3.1.0]hexane

HRID 371932ノート

反応式

HRID 371932 の反応式
[C:1]1([C:7]23[CH2:12][CH:11]2[CH2:10][NH:9][CH2:8]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1C=CC=CC=1.C(N(CC)CC)C.[CH:26]1([C:29](Cl)=[O:30])[CH2:28][CH2:27]1>O>[CH:26]1([C:29]([N:9]2[CH2:10][CH:11]3[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)([CH2:12]3)[CH2:8]2)=[O:30])[CH2:28][CH2:27]1

参加物

6

反応物 4

HCID 241Benzene2 回HCID 8471TriethylamineHCID 77637Cyclopropanecarbonyl chlorideHCID 101300941-Phenyl-3-azabicyclo[3.1.0]hexane

生成物 1

HCID 128913673-Cyclopropylcarbonyl-1-phenyl-3-azabicyclo[3.1.0]hexane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 15.9 g. of 1-phenyl-3-azabicyclo-[3.1.0]hexane in 100 ml. of benzene and 20 ml. of triethylamine is added 11.0 g. of cyclopropanecarboxylic acid chloride in 20 ml. of benzene over 5 minutes. The mixture is stirred for 30 minutes and 50 ml. of water is added. The benzene layer is extracted with dilute sodium bicarbonate followed by dilute hydrochloric acid and then water, dried over magnesium sulfate and evaporated to give the product as a brown oil.

後処理

  1. extractionThe benzene layer is extracted with dilute sodium bicarbonate
  2. dry with materialwater, dried over magnesium sulfate
  3. customevaporated

出典と根拠

ORDレコード
ord-6c7e786f5e7246dd812b2581f5b5eec3
出典データセット
uspto-grants-1978_05
特許番号
US04088652

反応ノート

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