Water → 1-Chloro-3-phenoxypropan-2-one

HRID 372070

反応式

HRID 372070 の反応式
CC(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O.[Cl:14][CH2:15][CH:16]([OH:25])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>CC(C)=O.[Cr]>[Cl:14][CH2:15][C:16]([CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:25]

参加物

6

反応物 3

HCID 962WaterHCID 943001-Chloro-3-phenoxy-2-propanolHCID 131709961Jones' reagent

生成物 1

HCID 116224561-Chloro-3-phenoxypropan-2-one収率 49.7%

試薬・触媒・溶媒 2

HCID 23976Chromium触媒HCID 180Acetone溶媒

反応条件

温度
20 °C

実験手順

8N Jones reagent (100 ml.) was added dropwise to a stirred solution of 1-chloro-2-hydroxy-3-phenoxypropane (28.3 g.) in acetone (100 ml.) during 1 hour while maintaining the reaction temperature at 20° C. The mixture was then stirred for 4 hours, and then sufficient water was added to dissolve the precipitated chromium salts. The mixture was extracted three times with diethyl ether and the combined ethereal extracts were dried over sodium sulphate, concentrated under reduced pressure, dried again over sodium sulphate, and concentrated further and distilled, to give 1-chloro-3-phenoxyacetone (13.9 g.), b.p. 150°-155° C./20 mm.Hg.

後処理

  1. extractionThe mixture was extracted three times with diethyl ether
  2. dry with materialthe combined ethereal extracts were dried over sodium sulphate
  3. concentrationconcentrated under reduced pressure
  4. dry with materialdried again over sodium sulphate
  5. concentrationconcentrated further
  6. distillationdistilled

出典と根拠

ORDレコード
ord-aebca0dd54214c77b0232d4af4effbc5
出典データセット
uspto-grants-1978_05
特許番号
US04088695

関連ノート

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