関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 1-(Pyridin-3-yl)butane-1,3-dione | HCID 300160 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Nicotinoyl-1-methylvinylamine | HCID 70618993 | 91% |
反応手順
7.5 g of nicotinoyl-acetone are dissolved in 45 ml of anhydrous ethanol and, after adding 20 ml of ammonia, the mixture is then stirred for 3 days at 50° C in an autoclave. Concentrating the clear solution leaves an oil which becomes solid after a short time. After recrystallisation from toluene, 2-nicotinoyl-1-methylvinylamine (melting point 82°) is obtained in a 91% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04088764 |
|---|
| 出典データセット | uspto-grants-1978_05 |
|---|
| ORD ID | ord-236d415899be4cbcb2df5fdbccba8ab2 |
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| 出典メモ | uspto-grants-1978_05 |
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