反応式
[C:1]([CH2:9][C:10](=O)[CH3:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[NH3:13]>C(O)C>[C:1]([CH:9]=[C:10]([NH2:13])[CH3:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
7.5 g of nicotinoyl-acetone are dissolved in 45 ml of anhydrous ethanol and, after adding 20 ml of ammonia, the mixture is then stirred for 3 days at 50° C in an autoclave. Concentrating the clear solution leaves an oil which becomes solid after a short time. After recrystallisation from toluene, 2-nicotinoyl-1-methylvinylamine (melting point 82°) is obtained in a 91% yield.
後処理
- concentrationConcentrating the clear solution
- customleaves an oil which
- customAfter recrystallisation from toluene
出典と根拠
- ORDレコード
- ord-236d415899be4cbcb2df5fdbccba8ab2
- 出典データセット
- uspto-grants-1978_05
- 特許番号
- US04088764
関連ノート
読み込み中…