Cyanamide → Metiamide

反応式

C(NC(N)=N)#N.[CH3:7][NH:8][C:9]([NH:11][CH2:12][CH2:13][S:14][CH2:15][C:16]1[N:17]=[CH:18][NH:19][C:20]=1[CH3:21])=[S:10].[N:22]#[C:23][NH2:24].N#CN.[Pb]>>[C:23]([NH:24][C:9]([NH:8][CH3:7])=[N:11][CH2:12][CH2:13][S:14][CH2:15][C:16]1[N:17]=[CH:18][NH:19][C:20]=1[CH3:21])#[N:22].[CH3:7][NH:8][C:9]([NH:11][CH2:12][CH2:13][S:14][CH2:15][C:16]1[N:17]=[CH:18][NH:19][C:20]=1[CH3:21])=[S:10]

参加物

反応物 4

HCID 9864Cyanamide

HCID 1548992Metiamide

HCID 22262466CH2N2Pb

HCID 178418324HCID 178418324、化合物

生成物 2

HCID 1548992Metiamide

HCID 178484998HCID 178484998、化合物

実験手順

The compounds of Formula I are also useful as intermediates in the production of cyanoguanidine compounds. For example N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea may be reacted with a heavy metal salt of cyanamide such as lead cyanamide to yield N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine, or N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea may be alkylated and the resultant isothiourea treated with a strong base and cyanamide to give N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine.

出典と根拠

ORDレコード: ord-73004e662a0e46d1a2d05c86b223ee06
出典データセット: uspto-grants-1978_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04090026

反応ノート

読み込み中…