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2-Hydroxyacetamide → 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Hydroxyacetamide | HCID 69021 | — |
| 反応物 | 2-(4-Chloro-2-methylphenoxy)acetaldehyde | HCID 12391459 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone | HCID 12391492 | 18.2% |
反応手順
A solution containing 4.6g (0.025 mole) of (4-chloro-2-methylphenoxy)acetaldehyde and 2.1g (0.028 mole) of glycolamide in 25 ml of tetrahydrofuran and 25 ml of ether was allowed to stand at ambient temperature for 24 hours. The resulting product was washed with 5% sodium carbonate and water, dried and purified by silica chromatography to give 1.1g of 2-(4-chloro-2-methylphenoxymethyl)-4-oxazolidinone as a white crystalline solid melting at 109°-112°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04090861 |
| 出典データセット | uspto-grants-1978_05 |
| ORD ID | ord-2005a2a0641041d69c36b39cd9a7f613 |
| 出典メモ | uspto-grants-1978_05 |