Hydrochloric Acid → 4-amino-3,4-dihydro-2H-naphthalen-1-one
反応式
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH:12]C(=O)C)[CH2:4][CH2:3]1.Cl>O>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH2:12])[CH2:4][CH2:3]1参加物
4
実験手順
A mixture of 41.4 g. of crude N-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)acetamide, 300 ml. of concentrated hydrochloric acid and 250 ml. of water is stirred and heated at reflux overnight. The mixture is decanted, filtered, and the cooled filtrate is extracted with 300 ml. of chloroform. The aqueous solution is evaporated to dryness in vacuo to afford 26.55 g. of the title product.
後処理
- additionA mixture of 41.4 g
- temperatureheated
- temperatureat reflux overnight
- customThe mixture is decanted
- filtrationfiltered
- extractionthe cooled filtrate is extracted with 300 ml
- customThe aqueous solution is evaporated to dryness in vacuo
- customto afford 26.55 g
出典と根拠
- ORDレコード
- ord-a0760faea9874285bc4d7a9d3c913d90
- 出典データセット
- uspto-grants-1978_05
- 特許番号
- US04091018
反応ノート
読み込み中…