Acetic Anhydride → (S)-N-(1,2,3,4-tetrahydro-1-naphthyl-1-naphthyl)acetamide

HRID 372398

反応式

HRID 372398 の反応式
[C@@H:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.C(O[C:16](=[O:18])[CH3:17])(=O)C>C1(C)C=CC=CC=1>[C@@H:9]1([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:1]=2[NH:11][C:16](=[O:18])[CH3:17])[C:10]2[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=2)[CH2:6][CH2:7][CH2:8]1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 70580741-Aminotetralin, (S)-

生成物 1

HCID 70619608(S)-N-(1,2,3,4-tetrahydro-1-naphthyl-1-naphthyl)acetamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

(S)-1,2,3,4-tetrahydro-1-naphthylamine (26.9 g.) is dissolved in 200 ml. of toluene and 36 g. of acetic anhydride is added while the temperature from the reaction exotherm is moderated at 50° C. to 60° C. with an ice-bath. The solution is heated to reflux for 0.5 hr. and then stirred at room temperature overnight. The mixture is then evaporated to dryness and the residue is washed well with ether. On drying, 26.1 g. of the title compound, m.p. 153° C. to 155° C., is obtained.

後処理

  1. customis moderated at 50° C. to 60° C. with an ice-bath
  2. temperatureThe solution is heated
  3. temperatureto reflux for 0.5 hr
  4. customThe mixture is then evaporated to dryness
  5. washthe residue is washed well with ether
  6. customOn drying

出典と根拠

ORDレコード
ord-e4665fed39504738b9c5d341cd336482
出典データセット
uspto-grants-1978_05
特許番号
US04091018

関連ノート

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