Dimethyl Sulfoxide → 2-(4-Methyl-phenoxy)-5-methyl-phenylacetonitrile

HRID 372419ノート

反応式

HRID 372419 の反応式
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH3:17])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=1.CS(C)=O.[C-:22]#[N:23].[Na+]>O>[CH3:16][C:13]1[CH:14]=[CH:15][C:10]([O:9][C:8]2[CH:7]=[CH:6][C:5]([CH3:17])=[CH:4][C:3]=2[CH2:2][C:22]#[N:23])=[CH:11][CH:12]=1

参加物

5

反応物 3

HCID 679Dimethyl Sulfoxide2 回HCID 8929Sodium CyanideHCID 227679253-Chloromethyl-4-(4-methyl-phenoxy)-toluene

生成物 1

HCID 543008532-(4-Methyl-phenoxy)-5-methyl-phenylacetonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
36 °C

実験手順

A solution of 108 g. of 3-chloromethyl-4-(4-methyl-phenoxy)-toluene in 70 ml. of dimethylsulfoxide is added dropwise at 20°-25° C. to a suspension of 23 g. of sodium cyanide in 35 ml. of dimethylsulfoxide. The mixture is subsequently stirred for 4 hours at 36° C., then diluted with 1 Liter of water and extracted three times with benzene. The benzene extracts are washed three times with water, then dried over sodium sulfate and evaporated in vacuo, and there is obtained crude 2-(4-methyl-phenoxy)-5-methyl-phenylacetonitrile as a brown oil.

後処理

  1. extractionextracted three times with benzene
  2. washThe benzene extracts are washed three times with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-eca506c98ec64343834b01ac343d56f6
出典データセット
uspto-grants-1978_05
特許番号
US04091023

反応ノート

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