Ethyl Acetate → 2-Amino-10,11-dihydro-dibenz[b,f]oxepin-10-one

HRID 372431ノート

反応式

HRID 372431 の反応式
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]2[O:8][C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[C:11](=[O:13])[CH2:12][C:6]=2[CH:5]=1)([O-])=O.C(OCC)(=O)C>[Pt]=O.C(O)C>[NH2:1][C:4]1[CH:19]=[CH:18][C:7]2[O:8][C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[C:11](=[O:13])[CH2:12][C:6]=2[CH:5]=1

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 2276785510,11-Dihydro-2-nitro-dibenz[b,f]oxepin-10-one

生成物 1

HCID 227679272-Amino-10,11-dihydro-dibenz[b,f]oxepin-10-one

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

52.5 G. of 10,11-dihydro-2-nitro-dibenz[b,f]oxepin-10-one are suspended in 900 ml. of ethyl acetate and 450 ml. of ethanol and hydrogenated in the presence of 300 mg. of platinum oxide at room temperature and normal pressure. The catalyst is removed by filtration, the filtrate evaporated in vacuo. The residue is crystallized from benzene/hexane, and there is obtained 2-amino-10,11-dihydro-dibenz[b,f]oxepin-10-one having a melting point of 116°-117° C.

後処理

  1. customat room temperature
  2. customThe catalyst is removed by filtration
  3. customthe filtrate evaporated in vacuo
  4. customThe residue is crystallized from benzene/hexane

出典と根拠

ORDレコード
ord-85a13657d23447c19f9dbd2721815614
出典データセット
uspto-grants-1978_05
特許番号
US04091023

反応ノート

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