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4-Chloro-8-(trifluoromethyl)quinoline → dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-8-(trifluoromethyl)quinoline | HCID 90262 | — |
| 反応物 | Dimethylphosphinylmethyl anthranilate | HCID 12669155 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate | HCID 12669152 | — |
反応手順
4.6 grams (0.02 mol) of dimethylphosphinylmethyl anthranilate and 4.6 grams (0.02 mol) of 4-chloro-8-trifluoromethylquinoline are kept at 80° C for about 31/2 hours in 15 ml of isopropanol and 2.3 ml of concentrated aqueous hydrochloric acid. After removing the solvents and excess hydrochloric acid, the free base of the ester is liberated at 0° C. The dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate obtained is identical to that prepared in Example (2a). Yield 7.6 grams (90% of theory).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04091095 |
| 出典データセット | uspto-grants-1978_05 |
| ORD ID | ord-73834c741bfc439da9a72fcec4cc69fd |
| 出典メモ | uspto-grants-1978_05 |