Ethyl 7-(methanesulfonamido)heptanoate → 7-[N-(4(R)-hydroxy-2-nonynyl)methanesulfonamido]heptanoic acid

HRID 372519ノート

反応式

HRID 372519 の反応式
CS(NCCCCCCC(OCC)=O)(=O)=O.C([O:20][CH:21]([CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])[CH2:22][CH2:23][CH2:24][N:25]([CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38]([O:40]CC)=[O:39])[S:26]([CH:29](C)C)(=[O:28])=[O:27])(=O)C>>[OH:20][C@H:21]([CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])[C:22]#[C:23][CH2:24][N:25]([CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38]([OH:40])=[O:39])[S:26]([CH3:29])(=[O:27])=[O:28]

参加物

3

反応物 2

HCID 12150839Ethyl 7-(methanesulfonamido)heptanoateHCID 20327709ethyl 7-[N-(4-acetoxynonyl)-1-methylethanesulfonamido]heptanoate

生成物 1

HCID 227984047-[N-(4(R)-hydroxy-2-nonynyl)methanesulfonamido]heptanoic acid

実験手順

The synthesis of this compound is carried out as described in Example 1 except that, in Step A, the ethyl 7-(methanesulfonamido)heptanoate is replaced by an equimolar amount of ethyl 7-[(1-methylethane)sulfonamido]heptanoate (Example R). The product of Step A is thus ethyl 7-[N-(4-acetoxynonyl)-1-methylethanesulfonamido]heptanoate. The subsequent step yields 7-[N-(4-hydroxynonyl)-1-methylethanesulfonamido]heptanoic acid (B).

後処理

  1. customThe synthesis of this compound

出典と根拠

ORDレコード
ord-91e6b31a00fb43d7bd800a289ef46fd7
出典データセット
uspto-grants-1978_05
特許番号
US04091107

反応ノート

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