ethyl 7-[N-(4-acetoxy-9,9,9-trifluorononyl)methanesulfonamido]heptanoate → 7-[N-(4(R)-hydroxy-2-nonynyl)methanesulfonamido]heptanoic acid

HRID 372527ノート

反応式

HRID 372527 の反応式
ClCCCC(OC(=O)C)CCCCC(F)(F)F.C([O:21][CH:22]([CH2:42][CH2:43][CH2:44][CH2:45][C:46](F)(F)F)[CH2:23][CH2:24][CH2:25][N:26]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][C:37]([O:39]CC)=[O:38])[S:27]([CH3:30])(=[O:29])=[O:28])(=O)C>>[OH:21][C@H:22]([CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])[C:23]#[C:24][CH2:25][N:26]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][C:37]([OH:39])=[O:38])[S:27]([CH3:30])(=[O:28])=[O:29]

参加物

3

反応物 2

HCID 20327693ethyl 7-[N-(4-acetoxy-9,9,9-trifluorononyl)methanesulfonamido]heptanoateHCID 203860351-Chloro-4-acetoxy-9,9,9-trifluorononane

生成物 1

HCID 227984047-[N-(4(R)-hydroxy-2-nonynyl)methanesulfonamido]heptanoic acid

実験手順

The synthesis of this compound is carried out as described in Example 1, except that, in Step A, the 1-chloro-4-acetoxy-9,9,9-trifluorononane (Example E). The product of Step A is thus ethyl 7-[N-(4-acetoxy-9,9,9-trifluorononyl)methanesulfonamido]heptanoate. The subsequent step yields 7-[N-(4-hydroxy-9,9,9-trifluorononyl)methanesulfonamido]heptanoic acid (B).

後処理

  1. customThe synthesis of this compound

出典と根拠

ORDレコード
ord-22b35a01fdee480692885be2f2b2a262
出典データセット
uspto-grants-1978_05
特許番号
US04091107

反応ノート

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