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1,1-Dimethylhydrazine → alpha-Dimethylhydrazinocarbonylamino-2-thiopheneacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1-Dimethylhydrazine | HCID 5976 | — |
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | alpha-Isocyanato-2-thiopheneacetic acid, ethyl ester | HCID 54068691 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | alpha-Dimethylhydrazinocarbonylamino-2-thiopheneacetic acid | HCID 54530029 | — |
反応手順
A solution of 4.2 g. (0.02 mole) of DL-α-isocyanato-2-thiopheneacetic acid, ethyl ester and 1.2 g. (0.02 mole) of N,N-dimethylhydrazine in 80 ml. of methylene chloride is stirred overnight. The solution is concentrated and to the syrupy residue are added 10 ml. of 2N sodium hydroxide solution. After stirring for 30 minutes, a clear yellow solution results. By the addition of acetic acid, 3.9 g. of α-dimethylhydrazinocarbonylamino-2-thiopheneacetic acid are obtained, m.p. 208°-210°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04091212 |
| 出典データセット | uspto-grants-1978_05 |
| ORD ID | ord-b094b609afb442189fcc9cf8dd7c8520 |
| 出典メモ | uspto-grants-1978_05 |