Ethylenediamine → 4-(6-Oxo-1,6-dihydropyridazin-3-yl)benzonitrile

HRID 372690

反応式

HRID 372690 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.[CH3:15][N:16](C)C=O.C(N)CN>O>[C:15]([C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1)#[N:16]

参加物

5

反応物 3

HCID 3301EthylenediamineHCID 6228DimethylformamideHCID 6890736-(4-Bromophenyl)-2,3-dihydropyridazin-3-one

生成物 1

HCID 194194914-(6-Oxo-1,6-dihydropyridazin-3-yl)benzonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 19.20 g. portion of 6-(p-bromophenyl)-3(2H)-pyridazinone is mixed with 9.10 g. of cuprous cyanide in 70 ml. of dimethylformamide and stirred at reflux temperature for 12 hours. The hot mixture is poured into a solution of 46 ml. of ethylenediamine in 230 ml. of water. The mixture is stirred at ice-bath temperature for 30 minutes and the solid is separated by filtration. A second crop forms in the filtrate which is collected and added to the first crop which is then washed with water yielding 6-(p-cyanophenyl)-3(2H)-pyridazinone.

後処理

  1. temperatureat reflux temperature for 12 hours
  2. additionThe hot mixture is poured into a solution of 46 ml
  3. customthe solid is separated by filtration
  4. customA second crop forms in the filtrate which is collected
  5. additionadded to the first crop which
  6. washis then washed with water

出典と根拠

ORDレコード
ord-4296f7fe678e41928dd3210e7571eb17
出典データセット
uspto-grants-1978_05
特許番号
US04092311

関連ノート

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