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Phosphorus oxychloride → 3-Chloro-6-(4-cyanophenyl)pyridazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 4-(6-Oxo-1,6-dihydropyridazin-3-yl)benzonitrile | HCID 19419491 | — |
| 生成物 | 3-Chloro-6-(4-cyanophenyl)pyridazine | HCID 6405256 | — |
反応手順
A 3.42 g. portion of 6-(p-cyanophenyl)-3(2H)-pyridazinone in 25 ml. of phosphorus oxychloride is stirred and heated at reflux temperature for 3 hours. Most of the excess phosphorus oxychloride is removed under reduced pressure. Cracked ice-water is added to the concentrate which is stirred until the excess phosphorus oxychloride hydrolyzes. The solid is collected by filtration, dried and recrystallized from dimethylformamide-water, yielding 6-(p-cyanophenyl)-3-chloropyridazine, m.p. 236°-238° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04092311 |
| 出典データセット | uspto-grants-1978_05 |
| ORD ID | ord-9412ad88d33840089a40008381090d26 |
| 出典メモ | uspto-grants-1978_05 |