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Phosphorus oxychloride → 3-(4-Bromophenyl)-6-chloropyridazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 6-(4-Bromophenyl)-2,3-dihydropyridazin-3-one | HCID 689073 | — |
| 生成物 | 3-(4-Bromophenyl)-6-chloropyridazine | HCID 6405255 | — |
反応手順
A mixture of 20.0 g. of 6-(p-bromophenyl)-3(2H)-pyridazinone (prepared as described in Example 1) in 100 ml. of phosphorus oxychloride is heated at reflux temperature for 41/2 hours. The excess phosphorus oxychloride is removed under reduced pressure and the residue is stirred with water-cracked ice to decompose the remaining phosphorus oxychloride. The product is recovered by filtration and recrystallized from dilute dimethylformamide yielding tan crystals, m.p. 201°-203° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04092311 |
| 出典データセット | uspto-grants-1978_05 |
| ORD ID | ord-b086c842a9df4bda8a2409b0ce4d4654 |
| 出典メモ | uspto-grants-1978_05 |