Bromine → 6-(p-bromophenyl)-5-methyl-3(2H)-pyridazinone
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.BrBr>C(O)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([CH3:15])=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1参加物
4
実験手順
A 2.67 g. portion of 6-(p-bromophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone (prepared as described in Example 38 of U.S. Pat. No. 3,824,271) is suspended in 20 ml. of acetic acid. A 1.91 g. (0.62 ml.) portion of bromine in 5 ml. of acetic acid is added dropwise, while the reaction mixture is heated on a steam bath. Heating is continued for an additional 30 minutes. The reaction mixture is poured into crushed ice. The resulting solid is recovered by filtration, washed with water and dried, yielding 6-(p-bromophenyl)-5-methyl-3(2H)-pyridazinone.
後処理
- temperatureis heated on a steam bath
- temperatureHeating
- additionThe reaction mixture is poured
- custominto crushed ice
- filtrationThe resulting solid is recovered by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-4a59ea2658314cef9afdbdd4505f8643
- 出典データセット
- uspto-grants-1978_05
- 特許番号
- US04092311
反応ノート
読み込み中…