1-Butanol → Methyl 3-[6-(m-nitrophenyl)-5-methyl-3-pyridazinyl]carbazate
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[N:15]=[N:14][C:13](Cl)=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[C:17]([O:21][CH3:22])(=[O:20])[NH:18][NH2:19].[CH2:23](O)CCC>>[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[N:15]=[N:14][C:13]([NH:19][NH:18][C:17]([O:21][CH3:22])=[O:20])=[CH:12][C:11]=2[CH3:23])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]参加物
4
実験手順
A mixture of 11.4 g. of 6-(m-nitrophenyl)-3-chloropyridazine, 8.25 g. of methyl carbazate and 150 ml. of n-butanol is refluxed for 3 hours. The solvent is removed and the oily redisue stirred with cold water. The solid is filtered to give 11.5 g. of crystals which are recrystallized from methanol-petroleum ether to give off-white crystals, m.p. 198°-199° C.
後処理
- additionA mixture of 11.4 g
- customThe solvent is removed