HCID 11673142、化合物 → HCID 53790063、化合物

HRID 372773ノート

反応式

HRID 372773 の反応式
ClC1C=C(Cl)C(Cl)=CC=1O[C:11](=[O:31])[C@H:12]([CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24][CH:23]=1)[NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15].[CH2:32]([O:39][C:40](=[O:47])[C@H:41]([CH2:43][CH2:44][S:45][CH3:46])[NH2:42])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>C(Cl)Cl>[CH2:32]([O:39][C:40](=[O:47])[C@H:41]([CH2:43][CH2:44][S:45][CH3:46])[NH:42][C:11](=[O:31])[C@H:12]([CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24][CH:23]=1)[NH:13][C:14]([O:16][C:17]([CH3:18])([CH3:20])[CH3:19])=[O:15])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

参加物

4

反応物 2

HCID 11673142HCID 11673142、化合物HCID 22788750N-t-butoxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester

生成物 1

HCID 53790063HCID 53790063、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 26.6 parts N-t-butoxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester and 12.0 parts L-methionine benzyl ester in 200 parts methylene chloride is stirred overnight at room temperature. The solvent is then removed by evaporation under reduced pressure. The crude dipeptide is then subjected to low-pressure column chromatography on silica gel to afford N-t-butoxycarbonyl-L-tryptophyl-L-methionine benzyl ester.

後処理

  1. customThe solvent is then removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-a64ffbc761fa40b7bf66da369a1f19f6
出典データセット
uspto-grants-1978_05
特許番号
US04092304

反応ノート

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