Hydrochloric Acid → HCID 70620434、化合物

HRID 372777ノート

反応式

HRID 372777 の反応式
C(OC([NH:8][C@H:9]([C:18]([NH:20][CH2:21][C:22]([NH:24][CH2:25][C:26]([NH:28][C@H:29]([C:40]([NH:42][C@H:43]([C:48]([OH:50])=[O:49])[CH2:44][CH2:45][S:46][CH3:47])=[O:41])[CH2:30][C:31]1[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[NH:33][CH:32]=1)=[O:27])=[O:23])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=O)(C)(C)C.[ClH:51]>O1CCOCC1>[ClH:51].[NH2:8][C@H:9]([C:18]([NH:20][CH2:21][C:22]([NH:24][CH2:25][C:26]([NH:28][C@H:29]([C:40]([NH:42][C@H:43]([C:48]([OH:50])=[O:49])[CH2:44][CH2:45][S:46][CH3:47])=[O:41])[CH2:30][C:31]1[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[NH:33][CH:32]=1)=[O:27])=[O:23])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 54048888HCID 54048888、化合物

生成物 1

HCID 70620434HCID 70620434、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

The N-t-butoxycarbonyl-L-tyrosylglycylglycyl-L-tryptophyl-L-methionine is dissolved in 100 parts dioxane and stirred with a ten-fold excess of 2 N hydrochloric acid at room temperature for 15 minutes. The solvent is then removed under reduced pressure and the residue is triturated with ethyl ether. The resulting solid is precipitated from the mixture of methanol and ether to afford L-tyrosylglycylglycyl-L-tryptophyl-L-methionine hydrochloride. This compound is represented by the following formula

後処理

  1. customThe solvent is then removed under reduced pressure
  2. customthe residue is triturated with ethyl ether
  3. customThe resulting solid is precipitated from the mixture of methanol and ether

出典と根拠

ORDレコード
ord-3bae411051c84cdba4204a9f6b597017
出典データセット
uspto-grants-1978_05
特許番号
US04092304

反応ノート

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