Benzyl L-leucinate → N-t-butoxycarbonylglycyl-L-leucine benzyl ester

HRID 372783ノート

反応式

HRID 372783 の反応式
ClC1C=C(Cl)C(Cl)=CC=1[O:10][C:11](=O)[CH2:12][NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15].[CH2:22]([O:29][C:30](=[O:37])[C@H:31]([CH2:33][CH:34]([CH3:36])[CH3:35])[NH2:32])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(Cl)Cl>[CH2:22]([O:29][C:30](=[O:37])[C@H:31]([CH2:33][CH:34]([CH3:35])[CH3:36])[NH:32][C:11](=[O:10])[CH2:12][NH:13][C:14]([O:16][C:17]([CH3:19])([CH3:18])[CH3:20])=[O:15])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

参加物

4

反応物 2

HCID 6451313Benzyl L-leucinateHCID 12799284t-Butoxycarbonylglycine-2,4,5-Trichlorophenyl Ester

生成物 1

HCID 53703413N-t-butoxycarbonylglycyl-L-leucine benzyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 19.5 parts N-t-butoxycarbonylglycine 2,4,5-trichlorophenyl ester and 11.1 parts L-leucine benzyl ester in 200 parts methylene chloride is stirred overnight at room temperature. The solvent is then removed by evaporation under reduced pressure. The crude dipeptide is then subjected to low-pressure column chromatography on silica gel to afford N-t-butoxycarbonylglycyl-L-leucine benzyl ester.

後処理

  1. customThe solvent is then removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-0ac71ffc126449cab9a5591baaaff651
出典データセット
uspto-grants-1978_05
特許番号
US04092304

反応ノート

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