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Methanol → 2-(1-Naphthyl)-2-(methoxycarbonyl)acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 1-Naphthaleneacetonitrile | HCID 8596 | — |
| 反応物 | Dimethyl Carbonate | HCID 12021 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 生成物 | 2-(1-Naphthyl)-2-(methoxycarbonyl)acetonitrile | HCID 10846815 | — |
反応手順
0.1 mol of 2-(1-naphthyl)acetonitrile is dissolved in 120 cm3 of dimethyl carbonate, and the solution is heated to reflux. 0.1 mol of sodium is then added in small portions over 30 min, during which time the methanol evaporates off. The reaction medium is kept refluxing for 1 hour, and the excess dimethyl carbonate is then evaporated off to dryness. The residue is taken up with 100 cm3 of an 18% solution of acetic acid in water.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05420158 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-87392b3e925043f0acdd97a4f40532ee |
| 出典メモ | uspto-grants-1995_05 |