Tetramethylammonium Hydroxide Pentahydrate → HCID 56990101、化合物

HRID 372971

反応式

HRID 372971 の反応式
[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:13][C:14]1[CH:15]=[C:16]([C:29]2[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=2)[CH:17]=[C:18]([CH2:20][P:21]([O:26][CH2:27][CH3:28])([O:23][CH2:24][CH3:25])=[O:22])[CH:19]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].O.O.O.O.O.[OH-].C[N+](C)(C)C.[CH2:47](Br)[CH:48]=[CH:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1>CN(C)C=O>[CH2:47]([O:11][C:10](=[O:12])[CH:9]([NH:8][C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[CH2:13][C:14]1[CH:15]=[C:16]([C:29]2[CH:30]=[CH:31][C:32]([Cl:35])=[CH:33][CH:34]=2)[CH:17]=[C:18]([CH2:20][P:21]([O:26][CH2:27][CH3:28])([O:23][CH2:24][CH3:25])=[O:22])[CH:19]=1)[CH:48]=[CH:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1

参加物

5

反応物 3

HCID 82620Tetramethylammonium Hydroxide PentahydrateHCID 98116BromomethylstyreneHCID 14127515HCID 14127515、化合物

生成物 1

HCID 56990101HCID 56990101、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 1.05 g of the product of step b) in 5 ml dimethylformamide are added 362 mg tetramethylammonium hydroxide pentahydrate. The mixture is stirred at room temperature 1 1/2 hours and then treated with 394 mg cinnamyl bromide. The mixture is stirred at room temperature 17 hours. The mixture is diluted with ice/water (about 50 ml) and extracted with diethyl ether. The extracts are washed with 10 ml aqueous 1N KHCO3 solution, dried (Na2SO4) and evaporated to give the heading compound as an oil.

後処理

  1. stirringThe mixture is stirred at room temperature 17 hours
  2. extractionextracted with diethyl ether
  3. washThe extracts are washed with 10 ml aqueous 1N KHCO3 solution
  4. dry with materialdried (Na2SO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-01be88585a0243e0b188c3ce031ecad4
出典データセット
uspto-grants-1992_11
特許番号
US05162311

関連ノート

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