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Pyrazole → 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrazole | HCID 1048 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-(4-(4-Bromobutyl)piperazin-1-yl)pyrimidine | HCID 14726843 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole | HCID 11044366 | — |
反応手順
A mixture of 4 g (13.3 mmol) of 1-(2-pyrimidinyl)-4-(4-bromobutyl)piperazine, 1.02 g (15 mmol) of pyrazole and 2.76 g (20 mmol) of potassium carbonate in 50 ml of dimethylformamide is heated to reflux for 14 hours. The mixture is evaporated under vacuum, chloroform is added, the organic phase is washed with water, dried over sodium sulphate and evaporated under vacuum, and 3.5 g of an oil which is 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05162323 |
| 出典データセット | uspto-grants-1992_11 |
| ORD ID | ord-88d5f208d48e4fefa8dfa751ff185f9e |
| 出典メモ | uspto-grants-1992_11 |