Triethylamine → 2-n-Butyl-5-ethyl-6-methylpyrimidin-4(3H)-one

HRID 373122

反応式

HRID 373122 の反応式
Cl.[C:2]([NH2:8])(=[NH:7])[CH2:3][CH2:4][CH2:5][CH3:6].[CH2:9]([CH:11]([C:17]([CH3:19])=O)[C:12](OCC)=[O:13])[CH3:10].C(N(CC)CC)C>CN(C=O)C.[Cl-].[Na+].O>[CH2:3]([C:2]1[NH:8][C:12](=[O:13])[C:11]([CH2:17][CH3:19])=[C:9]([CH3:10])[N:7]=1)[CH2:4][CH2:5][CH3:6]

参加物

6

反応物 3

HCID 8471TriethylamineHCID 79065Butanoic acid, 2-ethyl-3-oxo-, ethyl esterHCID 11615174Pentanimidamide Hydrochloride

生成物 1

HCID 1356254552-n-Butyl-5-ethyl-6-methylpyrimidin-4(3H)-one

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 57417360Sodium chloride; water溶媒

実験手順

A solution of 3.0 g valeramidine hydrochloride, 3.47 g ethyl 2-ethylacetoacetate, and 5.8 mL triethylamine in 20 mL DMF was heated to 120° C. for 18 hours. The mixture was diluted with brine and extracted three times with ether. The combined organic material was washed with brine, was dried over MgSO4, was stripped of solvent in vacuo, and then was still flash chromatographed in 3% MeOH in CH2Cl2 to give the title compound as a white solid.

後処理

  1. extractionextracted three times with ether
  2. washThe combined organic material was washed with brine
  3. dry with materialwas dried over MgSO4
  4. customchromatographed in 3% MeOH in CH2Cl2

出典と根拠

ORDレコード
ord-2c1dd5fc50af494f8e30ecfcd63b6475
出典データセット
uspto-grants-1992_11
特許番号
US05162325

関連ノート

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